Match is played in Allegiant Stadium
The Raiders took an early 7-0 lead in the first quarter on a touchdown pass from Derek Carr to Darren Waller.
The 49ers responded with a touchdown drive of their own to tie the game at 7-7 in the second quarter.
The Raiders scored 21 unanswered points in the second half to take a 28-7 lead.
The 49ers scored two touchdowns in the fourth quarter to cut the lead to 28-17, but they were unable to get the ball back for a potential game-winning drive.
Jacobs ran for a 6-yard touchdown in the fourth quarter to give the Raiders a 28-17 lead.